{"id":7086,"date":"2024-10-18T14:25:22","date_gmt":"2024-10-18T07:25:22","guid":{"rendered":"https:\/\/thewriteria.com\/mentors\/ly-nguyen\/"},"modified":"2026-06-09T13:28:42","modified_gmt":"2026-06-09T06:28:42","slug":"ly-nguyen","status":"publish","type":"mentors","link":"https:\/\/thewriteria.com\/en\/mentors\/ly-nguyen\/","title":{"rendered":"Ly Nguyen"},"content":{"rendered":"\t\t<div data-elementor-type=\"wp-post\" data-elementor-id=\"7086\" class=\"elementor elementor-7086\" data-elementor-post-type=\"mentors\">\n\t\t\t\t<div class=\"elementor-element elementor-element-913cb0a e-flex e-con-boxed e-con e-parent\" data-id=\"913cb0a\" data-element_type=\"container\" data-e-type=\"container\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;,&quot;jet_parallax_layout_list&quot;:[],&quot;ekit_has_onepagescroll_dot&quot;:&quot;yes&quot;}\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t<div class=\"elementor-element elementor-element-e306359 e-con-full e-flex e-con e-child\" data-id=\"e306359\" data-element_type=\"container\" data-e-type=\"container\" data-settings=\"{&quot;jet_parallax_layout_list&quot;:[],&quot;ekit_has_onepagescroll_dot&quot;:&quot;yes&quot;}\">\n\t\t\t\t<div class=\"elementor-element elementor-element-b312014 elementor-widget elementor-widget-jet-listing-dynamic-image\" data-id=\"b312014\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;ekit_we_effect_on&quot;:&quot;none&quot;}\" data-widget_type=\"jet-listing-dynamic-image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div class=\"jet-listing jet-listing-dynamic-image\" ><img fetchpriority=\"high\" decoding=\"async\" width=\"1080\" height=\"1080\" src=\"https:\/\/thewriteria.com\/wp-content\/uploads\/2024\/10\/Mentor-Ly-Nguyen-1.webp\" class=\"jet-listing-dynamic-image__img attachment-full size-full wp-post-image\" alt=\"Mentor Ly Nguyen\" loading=\"eager\" \/><\/div>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-c50884d e-con-full e-flex e-con e-child\" data-id=\"c50884d\" data-element_type=\"container\" data-e-type=\"container\" data-settings=\"{&quot;jet_parallax_layout_list&quot;:[],&quot;ekit_has_onepagescroll_dot&quot;:&quot;yes&quot;}\">\n\t\t\t\t<div class=\"elementor-element elementor-element-c006b73 elementor-widget elementor-widget-jet-listing-dynamic-field\" data-id=\"c006b73\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;ekit_we_effect_on&quot;:&quot;none&quot;}\" data-widget_type=\"jet-listing-dynamic-field.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div class=\"jet-listing jet-listing-dynamic-field display-inline\"><div class=\"jet-listing-dynamic-field__inline-wrap\"><div class=\"jet-listing-dynamic-field__content\" >Ly Nguyen<\/div><\/div><\/div>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-2beb0eb elementor-widget elementor-widget-jet-listing-dynamic-field\" data-id=\"2beb0eb\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;ekit_we_effect_on&quot;:&quot;none&quot;}\" data-widget_type=\"jet-listing-dynamic-field.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div class=\"jet-listing jet-listing-dynamic-field display-inline\"><div class=\"jet-listing-dynamic-field__inline-wrap\"><div class=\"jet-listing-dynamic-field__content\" ><\/div><\/div><\/div>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-b95f14a elementor-widget elementor-widget-jet-listing-dynamic-field\" data-id=\"b95f14a\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;ekit_we_effect_on&quot;:&quot;none&quot;}\" data-widget_type=\"jet-listing-dynamic-field.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div class=\"jet-listing jet-listing-dynamic-field display-inline\"><div class=\"jet-listing-dynamic-field__inline-wrap\"><div class=\"jet-listing-dynamic-field__content\" >Scientist at Intellia Therapeutics<\/div><\/div><\/div>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-f55e328 elementor-widget elementor-widget-jet-listing-dynamic-field\" data-id=\"f55e328\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;ekit_we_effect_on&quot;:&quot;none&quot;}\" data-widget_type=\"jet-listing-dynamic-field.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div class=\"jet-listing jet-listing-dynamic-field display-inline\"><div class=\"jet-listing-dynamic-field__inline-wrap\"><div class=\"jet-listing-dynamic-field__content\" ><p><strong>An innovative molecular and cellular biologist with more than 10 years of academic and industry experience in cancer research, drug discovery, and cell therapy.<\/strong><\/p>\n<ul>\n<li>Developed a novel cell-based potency assay to support Phase III regulatory submissions for a gene therapy product.<\/li>\n<li>Led the development of multiple multicolor CAR-T cell-based release assays for the company\u2019s first CAR-T cell therapy product.<\/li>\n<li>Successfully designed and developed two analytical methods from early-stage development through qualification for multiple drug development programs.<\/li>\n<li>Discovered novel regulatory functions of proteins involved in cancer biology during PhD research, resulting in six peer-reviewed publications, including three first-author papers in the fields of cell biology and cancer research.<\/li>\n<li>Demonstrated strong leadership by managing two junior scientists and leading the AD release assay development team.<\/li>\n<\/ul>\n<\/div><\/div><\/div>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-8e8a1cf e-flex e-con-boxed e-con e-parent\" data-id=\"8e8a1cf\" data-element_type=\"container\" data-e-type=\"container\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;,&quot;jet_parallax_layout_list&quot;:[],&quot;ekit_has_onepagescroll_dot&quot;:&quot;yes&quot;}\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t<div class=\"elementor-element elementor-element-3df6044 e-con-full e-flex e-con e-child\" data-id=\"3df6044\" data-element_type=\"container\" data-e-type=\"container\" data-settings=\"{&quot;jet_parallax_layout_list&quot;:[],&quot;ekit_has_onepagescroll_dot&quot;:&quot;yes&quot;}\">\n\t\t\t\t<div class=\"elementor-element elementor-element-58a9f1d elementor-widget elementor-widget-heading\" data-id=\"58a9f1d\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;ekit_we_effect_on&quot;:&quot;none&quot;}\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">D\u1ecbch V\u1ee5<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-0a011c5 elementor-widget elementor-widget-heading\" data-id=\"0a011c5\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;ekit_we_effect_on&quot;:&quot;none&quot;}\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">L\u0129nh V\u1ef1c<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-6594022 elementor-widget elementor-widget-jet-listing-dynamic-terms\" data-id=\"6594022\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;ekit_we_effect_on&quot;:&quot;none&quot;}\" data-widget_type=\"jet-listing-dynamic-terms.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div class=\"jet-listing jet-listing-dynamic-terms\"><\/div>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-f155993 elementor-widget elementor-widget-heading\" data-id=\"f155993\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;ekit_we_effect_on&quot;:&quot;none&quot;}\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">Nation<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-89a1b23 elementor-widget elementor-widget-jet-listing-dynamic-terms\" data-id=\"89a1b23\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;ekit_we_effect_on&quot;:&quot;none&quot;}\" data-widget_type=\"jet-listing-dynamic-terms.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div class=\"jet-listing jet-listing-dynamic-terms\"><a href=\"https:\/\/thewriteria.com\/en\/country\/us\/\" class=\"jet-listing-dynamic-terms__link\">US<\/a><\/div>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-6dd2f10 elementor-widget elementor-widget-heading\" data-id=\"6dd2f10\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;ekit_we_effect_on&quot;:&quot;none&quot;}\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">Scholarship<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-3476e70 elementor-widget elementor-widget-jet-listing-dynamic-terms\" data-id=\"3476e70\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;ekit_we_effect_on&quot;:&quot;none&quot;}\" data-widget_type=\"jet-listing-dynamic-terms.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div class=\"jet-listing jet-listing-dynamic-terms\"><\/div>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-2659f2f elementor-widget elementor-widget-heading\" data-id=\"2659f2f\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;ekit_we_effect_on&quot;:&quot;none&quot;}\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">H\u1ecdc V\u1ea5n<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-b3661d4 elementor-widget elementor-widget-jet-listing-dynamic-field\" data-id=\"b3661d4\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;ekit_we_effect_on&quot;:&quot;none&quot;}\" data-widget_type=\"jet-listing-dynamic-field.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div class=\"jet-listing jet-listing-dynamic-field display-inline\"><div class=\"jet-listing-dynamic-field__inline-wrap\"><div class=\"jet-listing-dynamic-field__content\" ><p><strong>2017 \u2013 2022 | Johns Hopkins University School of Medicine<\/strong><br \/>\nPhD in Biochemistry, Cellular and Molecular Biology<\/p>\n<p><strong>2012 \u2013 2016 | University of California, Los Angeles (UCLA)<\/strong><br \/>\nBachelor of Science in Biology, Evolutionary Medicine Major<br \/>\nValedictorian Graduate<\/p>\n<\/div><\/div><\/div>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-cc68acb elementor-widget elementor-widget-heading\" data-id=\"cc68acb\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;ekit_we_effect_on&quot;:&quot;none&quot;}\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">Th\u00f4ng Tin Th\u00eam<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-1297c2d elementor-widget elementor-widget-jet-listing-dynamic-field\" data-id=\"1297c2d\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;ekit_we_effect_on&quot;:&quot;none&quot;}\" data-widget_type=\"jet-listing-dynamic-field.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div class=\"jet-listing jet-listing-dynamic-field display-inline\"><div class=\"jet-listing-dynamic-field__inline-wrap\"><div class=\"jet-listing-dynamic-field__content\" ><h3>Presentations &amp; Posters<\/h3>\n<p><strong>December 2022 | 7th Biannual Frontiers in Cytokinesis Conference &amp; American Society for Cell Biology (ASCB) Annual Meeting 2022<\/strong><br \/>\n<strong>Oral Presentation:<\/strong> <em>Discoidin I, a Classical Lectin, Functions Intracellularly to Support Contractility Machinery Assembly<\/em><\/p>\n<p><strong>February 2022 | Biophysical Society Annual Meeting 2022<\/strong><br \/>\n<strong>Poster Presentation:<\/strong> <em>Discoidin I, a Classical Lectin, Functions Intracellularly to Support Contractility Machinery Assembly<\/em><\/p>\n<p><strong>December 2020 | Cell Bio Virtual 2020 (ASCB | EMBO Joint Meeting)<\/strong><br \/>\n<strong>Poster Presentation:<\/strong> <em>Deciphering the Role of Discoidin Proteins in Regulating Cellular Mechanics<\/em><\/p>\n<p><strong>December 2019 | American Society for Cell Biology (ASCB) Annual Meeting 2019<\/strong><br \/>\n<strong>Poster Presentation:<\/strong> <em>The Function of Discoidin I in Regulating Cell Mechanics<\/em><\/p>\n<p><strong>June 2019 | Annual Medical Research Symposium, Vietnam\u2013UK Institute<\/strong><br \/>\n<strong>Oral Presentation:<\/strong> <em>Understanding Cell Mechanics and the Impact of Small Molecules on Contractility Systems<\/em><\/p>\n<p><strong>March 2015 | 7th GTCbio Ophthalmic Drug Discovery Conference<\/strong><br \/>\n<strong>Poster Presentation:<\/strong> <em>Discovery of Novel Trophic Factors that Protect Photoreceptor Cells from Degeneration<\/em><\/p>\n<h3>Leadership &amp; Service<\/h3>\n<p><strong>Apr 2021 \u2013 Present | Graduate Program Representative, Johns Hopkins School of Medicine Graduate Student Association (GSA)<\/strong><\/p>\n<ul>\n<li>Represent the needs and interests of more than 200 graduate students regarding research training, academic development, and student well-being.<\/li>\n<li>Draft and distribute newsletters featuring institutional updates, social events, professional development opportunities, and funding announcements.<\/li>\n<\/ul>\n<p><strong>Oct 2021 \u2013 Present | Policy and Programming Committee Member, Johns Hopkins School of Medicine Graduate Student Association (GSA)<\/strong><\/p>\n<ul>\n<li>Analyze student feedback on institutional policies and graduate training effectiveness and report findings to GSA leadership.<\/li>\n<li>Identify operational challenges within the GSA and propose solutions to improve student engagement and organizational effectiveness.<\/li>\n<\/ul>\n<p><strong>Sep 2019 \u2013 Present | Program Coordinator, Global Vietnamese Young Scholars Forum (GYVSF)<\/strong><\/p>\n<ul>\n<li>Organized annual forums connecting more than 300 Vietnamese scientists and young scholars worldwide to discuss education, science, technology, and innovation with senior government leaders, including the Vice President of Vietnam.<\/li>\n<li>Coordinated conference programming, workshop development, event logistics, and community-building activities for annual meetings.<\/li>\n<\/ul>\n<\/div><\/div><\/div>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-bce138c e-con-full e-flex e-con e-child\" data-id=\"bce138c\" data-element_type=\"container\" data-e-type=\"container\" data-settings=\"{&quot;jet_parallax_layout_list&quot;:[],&quot;ekit_has_onepagescroll_dot&quot;:&quot;yes&quot;}\">\n\t\t\t\t<div class=\"elementor-element elementor-element-6f6a7d8 elementor-widget elementor-widget-heading\" data-id=\"6f6a7d8\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;ekit_we_effect_on&quot;:&quot;none&quot;}\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">Th\u00e0nh T\u1ef1u<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-e1422c6 elementor-widget elementor-widget-jet-listing-dynamic-field\" data-id=\"e1422c6\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;ekit_we_effect_on&quot;:&quot;none&quot;}\" data-widget_type=\"jet-listing-dynamic-field.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div class=\"jet-listing jet-listing-dynamic-field display-inline\"><div class=\"jet-listing-dynamic-field__inline-wrap\"><div class=\"jet-listing-dynamic-field__content\" ><ul>\n<li>Valedictorian graduate of UCLA\u2019s Bachelor of Science in Biology program.<\/li>\n<li>Recipient of a fully funded PhD scholarship in Biomedical Sciences at Johns Hopkins University School of Medicine.<\/li>\n<li>Author of 7 international Q1 scientific publications.<\/li>\n<li>Received PhD interview and admission invitations from leading institutions, including MIT, UCLA, UC San Diego, Cornell University, and others.<\/li>\n<li>More than 10 years of academic research experience in molecular and cellular biology, with a particular focus on cancer biology and oncology research.<\/li>\n<li>Currently a Scientist at Intellia Therapeutics, a leading biotechnology company pioneering CRISPR-based gene editing therapies.<\/li>\n<\/ul>\n<\/div><\/div><\/div>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-69c1b1c elementor-widget elementor-widget-heading\" data-id=\"69c1b1c\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;ekit_we_effect_on&quot;:&quot;none&quot;}\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">Kinh Nghi\u1ec7m L\u00e0m Vi\u1ec7c<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-abd7744 elementor-widget elementor-widget-jet-listing-dynamic-field\" data-id=\"abd7744\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;ekit_we_effect_on&quot;:&quot;none&quot;}\" data-widget_type=\"jet-listing-dynamic-field.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div class=\"jet-listing jet-listing-dynamic-field display-inline\"><div class=\"jet-listing-dynamic-field__inline-wrap\"><div class=\"jet-listing-dynamic-field__content\" ><h3>Professional Experience<\/h3>\n<p><strong>Jan 2023 \u2013 Present | Scientist, Analytical Development \u2013 Potency, Technical Operations, Intellia Therapeutics<\/strong><\/p>\n<ul>\n<li>Develop cell-based release assays to evaluate CAR expression, on-target activity, and immunophenotyping for CAR-T cell therapy products.<\/li>\n<li>Developed flow cytometry- and MSD-based potency assays for gene therapy products to support Phase III clinical regulatory submissions.<\/li>\n<li>Perform MSD, ddPCR, and RT-ddPCR analyses to assess potency of lipid nanoparticle (LNP)-based products across multiple gene and cell therapy programs.<\/li>\n<li>Established knockout (KO) and overexpression (OE) cell lines using lipid nanoparticles (LNPs) and AAV vectors to support analytical assay development.<\/li>\n<li>Designed pre-qualification and qualification strategies for potency and release assays and led method transfer activities to contract manufacturing organizations (CMOs).<\/li>\n<li>Author of four flow cytometry- and MSD-based potency assays and two analytical development reports supporting multiple gene and cell therapy programs.<\/li>\n<\/ul>\n<p><strong>Jun 2022 \u2013 Sep 2022 | Analytical Development Intern, Gene &amp; Cell Therapy, Novartis Pharmaceuticals<\/strong><\/p>\n<ul>\n<li>Performed RNA isolation and developed a novel gene expression platform for transcriptomic analysis of CAR-T products.<\/li>\n<li>Conducted T-cell activation studies and evaluated potency and cytokine release in autologous cell therapy products using ELISA and MSD.<\/li>\n<li>Performed multicolor flow cytometry and intracellular staining to assess quality and functionality of final CAR-T products.<\/li>\n<li>Supported the generation of CD20+ luciferase-expressing B-cell banks for cytotoxicity and other analytical assays.<\/li>\n<li>Independently designed, executed, and documented analytical experiments in compliance with GxP standards.<\/li>\n<\/ul>\n<p><strong>Jun 2018 \u2013 Present | PhD Researcher, Robinson Laboratory, Johns Hopkins University School of Medicine<\/strong><\/p>\n<p><strong>Project 1: Identification of the molecular targets of 4-HAP, a potential anti-cancer therapeutic, in pancreatic ductal adenocarcinoma (PDAC)<\/strong><\/p>\n<ul>\n<li>Demonstrated the anti-cancer potential of 4-HAP and identified its therapeutic targets using a range of 2D and 3D experimental models.<\/li>\n<li>Developed two novel approaches utilizing fluorescence chromatography and cellular thermal shift assays (CETSA) to characterize protein\u2013drug interactions.<\/li>\n<li>Produced baculovirus particles and performed cell transduction to generate purified recombinant non-muscle myosin IIC proteins.<\/li>\n<li>Purified full-length myosin IIC and functional domains for in vitro interaction studies using affinity chromatography techniques.<\/li>\n<\/ul>\n<p><strong>Project 2: Investigating the role of Discoidin I in contractility and cancer cell dissemination<\/strong><\/p>\n<ul>\n<li>Discovered novel functions of Discoidin I as a regulator of cytokinesis, cell migration, and potentially cancer metastasis.<\/li>\n<li>Generated more than five knockout cell lines using CRISPR\/Cas9 and RNAi technologies and developed cell-based assays to characterize mutant phenotypes.<\/li>\n<li>Designed expression plasmids for CRISPR components and fluorescently tagged proteins using molecular cloning strategies.<\/li>\n<li>Performed lentiviral transduction and transfection to establish eight recombinant protein-expressing cell lines.<\/li>\n<li>Evaluated protein and mRNA expression changes in key contractility-associated factors following Discoidin I depletion.<\/li>\n<li>Conducted high-content imaging and microscopy analyses to identify differential protein localization patterns across mutant cell lines.<\/li>\n<\/ul>\n<p><strong>Jun 2016 \u2013 May 2017 | Research Assistant, Sun Laboratory, Jules Stein Eye Institute, UCLA<\/strong><\/p>\n<ul>\n<li>Conducted in vivo evaluation of novel anti-angiogenic compounds in mouse models of tumor growth and vascular development.<\/li>\n<li>Generated multiple mouse models to assess the efficacy of newly identified anti-angiogenic drug candidates.<\/li>\n<li>Performed subcutaneous and intraperitoneal injections, tissue collection, processing, and downstream analyses.<\/li>\n<\/ul>\n<p><strong>Sep 2013 \u2013 Jun 2016 | Undergraduate Researcher, Sun Laboratory, David Geffen School of Medicine at UCLA<\/strong><\/p>\n<ul>\n<li>Investigated novel natural compounds that protect photoreceptor cells against age-related retinal degeneration.<\/li>\n<li>Performed multi-step chromatography and mass spectrometry analyses to isolate and identify protective compounds.<\/li>\n<li>Developed cell injury and survival assays in primary photoreceptor cell models to evaluate therapeutic potential.<\/li>\n<\/ul>\n<p><strong>Jun 2019 \u2013 Present | Research Mentor, Summer Academic Research Experience (SARE), Johns Hopkins University<\/strong><\/p>\n<ul>\n<li>Mentored more than 20 high school students from underserved backgrounds across six Baltimore public schools, providing exposure to modern scientific research and academic career pathways.<\/li>\n<\/ul>\n<\/div><\/div><\/div>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-900aaaa elementor-widget elementor-widget-heading\" data-id=\"900aaaa\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;ekit_we_effect_on&quot;:&quot;none&quot;}\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">B\u00e0i B\u00e1o Khoa H\u1ecdc<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-d620ffd elementor-widget elementor-widget-jet-listing-dynamic-field\" data-id=\"d620ffd\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;ekit_we_effect_on&quot;:&quot;none&quot;}\" data-widget_type=\"jet-listing-dynamic-field.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div class=\"jet-listing jet-listing-dynamic-field display-inline\"><div class=\"jet-listing-dynamic-field__inline-wrap\"><div class=\"jet-listing-dynamic-field__content\" ><h3>Selected Publications<\/h3>\n<ul>\n<li style=\"list-style-type: none\">\n<ul>\n<li><strong>Liu, L., Leng, J., Nguyen, L.T.S., Robinson, D.N.<\/strong> RNA-binding protein 1A (RNP1A), a mechanosensing network protein, cooperates with contractility machinery proteins to facilitate micropinocytosis. <em>Manuscript in revision<\/em>, 2022.<\/li>\n<li><strong>Plaza-Rodr\u00edguez, A.I., Nguyen, L.T.S., Robinson, D.N., Iglesias, P.A.<\/strong> A particle-based model of mechanosensitive contractility machinery assembly. <em>Biophysical Journal<\/em>, 2022. <em>In press<\/em>.<\/li>\n<li><strong>Nguyen, L.T.S., Robinson, D.N.<\/strong> Discoidin I, a classical lectin, functions intracellularly to support contractility machinery assembly. <em>Journal of Cell Biology<\/em>. 2022;221(11):e202202063. DOI: 10.1083\/jcb.202202063.<\/li>\n<li><strong>Nguyen, L.T.S., Jacob, M.A., Paraj\u00f3n, E., Robinson, D.N.<\/strong> Cancer as a physical disease: targeting the mechanoadaptive program. <em>Biophysical Journal<\/em>. 2022;121(19):3573\u20133585. DOI: 10.1016\/j.bpj.2022.04.039.<\/li>\n<li><strong>Nguyen, L.T.S., Robinson, D.N.<\/strong> Unusual suspects in cytokinesis: putting the pieces together. <em>Frontiers in Cell and Developmental Biology<\/em>. 2020;8:441. DOI: 10.3389\/fcell.2020.00441.<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<\/div><\/div><\/div>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"<p>Ly Nguy\u1ec5n Th\u1ea1c S\u0129 Nh\u00e0 khoa h\u1ecdc t\u1ea1i c\u00f4ng ty Intellia Therapeutics M\u1ed9t nh\u00e0 sinh h\u1ecdc ph\u00e2n t\u1eed\/sinh h\u1ecdc t\u1ebf [&hellip;]<\/p>\n","protected":false},"featured_media":7260,"parent":0,"menu_order":1,"template":"","meta":{"site-sidebar-layout":"no-sidebar","site-content-layout":"","ast-site-content-layout":"full-width-container","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"disabled","ast-breadcrumbs-content":"","ast-featured-img":"disabled","footer-sml-layout":"","ast-disable-related-posts":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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